CHARACTERS
WoRC does a mostly good job with its characters, both as their own entities, and as representations of game ones. None of them are going to win any prizes for in-depth character writing (they're about on the level of the Anderson films), but unlike said Anderson films, there's no one character that's stealing the show over others, and the banter generally feels natural. Not all characters get equal screentime (as you might have guessed, Claire and Leon get far more material than Jill and Chris for instance), but overall, they're decent. Concerning key points however, going to bring up the following:
-Poor Chris. He's the closest thing the games have to a main character, but he probably gets the least screentime out of the 'big four,' and the least development. Probably his crowning glory is in the Spencer Mansion where he fights his way through hordes of zombies (see above), but he gets a 1v1 with Birkin that falls flat, because while it's established that Chris looks up to Birkin (since he had a role in the orphanage, and is implied to have sponsered Chris through academia/training), and the confrontation brings it up, it falls kind of flat.
-Jill's low-key insane, in a good way. She's wildly different from her game character, but if you like the archtype of "badass chick who's a bit crazy, but really good at what she does, and will always have your back," then you'll like Jill. For me, this version of Jill won't win any points for adaptive loyalty, but as a character in her own right, she's fun.
-Claire is in a similar position as Jill as far as "loyalty vs. execution" goes. As a character, she's fine, and benefits from being the main character of the film, and ergo, has the most development, whereas on the other, there isn't that much resemblance between this Claire and game!Claire. The one we see here is tough, no nonsense, hyper-competent, etc. However, this really doesn't sync with Claire from the games. This Claire doesn't even get a moment with Sherry in the film.
-I've seen a lot of people complain about Leon here, and I don't really get why. The Leon here is kind of clueless, naieve, very much a rookie, etc. You can argue that that's a divergence from how he is in RE2, but it's no more drastic a divergence than the other characters, and if anything, I think this captures his naievete in RE2. That, and he's really the only character that has a character arc, in that by the end, he's gone from "absolute loser" to "yeah, I just used a rocket launcher to kill Birkin, go me." Probably helps that he gets some of the best lines.
-Wesker here isn't Wesker. Like, at all. As in, you could name "Wesker" here John Doe, and it would make about as much sense. He looks completely different, acts completely different, and is a completely different person. The Wesker here is generally jovial, friendly, is being paid by a third party to retrieve the G-virus because so sick of being in Raccoon, he wants the money for a new life, yet he takes Jill with him in the Spencer Mansion, the implication being that while he knows Raccoon will be destroyed, he wants her to survive at least. And even then, his reluctance to kill at the end is what seals his fate, and he gives a genuine goodbye to his teammates, expressing remorse. By the end, he's revived (somehow...how his body was even retrieved is a mystery) and gets his trademark shades (as the revival process has made his eyes hyper-sensitive), but apart from that? Christ, they didn't even dye his hair.
So on one hand, the Wesker in the film is one of its best characters - morally ambiguous, but still a decent person driven to do things that...well, actually aren't that terrible, and understandable. But as a representation of Wesker? It's the complete opposite.
-Brian Irons: I really like this take on Irons. He isn't true to either his RE2 or RE2make personas, but what we have is a foul-mouthed, loud-mouthed, cowardly asshole. Nice.
-STARS: Grouping these together, because the remaining STARS members are redshirts. We have Vickers and Aiken on Alpha Team, and Marini and Dooley form Bravo Team, despite being patrol officers rather than any kind of SWAT-esque unit. Barry and Rebecca are nowhere to be seen, or even mentioned. Fine with redshirts - someone needs to die horribly for the sake of drama - but as far as faithfulness goes? Yeah.
-The Birkins: William Birkin is wasted here. Of what we do see of him, McDonaghuh does a great job, in that he's able to portray him as both a kind, caring figure to Sherry and the orphanage (even if it's a front), while also being downright sinister. Unfortunately, we don't see much of him. He and his family leave the house, then are absent for most of the movie where they're in a lab (somehow), and the story picks up from there. Annette is a redshirt, and Sherry...you could write Sherry out of the film and not miss anything. Seriously, after her father is killed, I don't think she has a single line, and no-one really acknowledges her presence. It doesn't even address the bond she has with Leon and Claire, as really, it's Chris and Jill who are the ones who save her.
-The Others: Lisa Trevor is neat, but is a hero rather than a villain. Ben Bertolucci doesn't get much screentime, but what he does get is good. And there's a character who cameos at the end, who's...fine, I guess?
OVERALL
Overall, I quite enjoyed this movie, but it has some significant flaws that do pile up towards the end. I think combining RE1 & 2 really hurt this film, and while I get that staying with just one could have become monotonous, things are stretched thin, and aren't stretched evenly. As its own thing, it's a fun zombie romp. As an adaptation, it's decent, but takes significant liberties and cuts a lot out. Frankly, anyone who says that games are inherently inferior to films in storytelling can be presented with this in contrast to the RE2, the RE2make, or RE1make (maybe not vanilla) and be corrected.
If we're comparing this to the Anderson films however, I'm still on the fence about that. Ranking the Anderson films here and now, for me, it goes 1>3>2>6>5 (again, haven't seen Afterlife). WtRC would fit somewhere in the 1-3-2 range. Easily better than Retribution and Final Chapter, but I'm not sure where it ranks with the first three. It's a better adaptation, sure, but a better film? Jury's still out on that.