First of all, let me start out by saying that, yes, I know that the title sounds pretentious. I apologize, but I honestly wasn't sure what else to call it. Second of all, let me explain what this thread is and isn't. This thread is meant to list anime series that you would say have "artistic merit." Anime series that are a little more thematically complex, or that are in some way experimental. It could be the writing, the direction, the animation techniques, ect. There is nothing wrong with enjoying My Hero Academia, or Attack on Titan, but that isn't quite what we're looking for here. I do not promise that everyone will enjoy all of the anime series on this list. You won't. Nor am I saying that an anime series is bad, just because I don't list it. I haven't seen everything, and even if I have, you may disagree with me on how much merit it has. I may not have even heard of it. This is just a list for people who may want to start watching anime series that are outside of the typical yearly summer shonen series. Furthermore, I will be excluding certain popular creators. Neon Genesis Evangelion, Berserk, and the works of miyazaki are some of the greatest works of animation ever made. However, most people have heard of these already. If you haven't, you should watch them first. There is a lot of other great material that doesn't receive much attention. I will try to organize series by their creator. If you like one series by a creator, you may like the others. If you hate their series or films, then you may dislike their style. Feel free to discuss the series mentioned, or add your own. I'll start with some of the more obvious series, and work my way down.
Anime
Isao Takahata: Grave of the Fireflies, The Tale of Princess Kaguya, Only Yesterday, Pom Poko, My Neighbors the Yamada's,
Satoshi Kon: Perfect Blue, Millenium Actress, Tokyo Godfathers, Paprika, Paranoia Agent, Memories (the short film, magnetic rose)
Chiaki Konaka: Serial Experiments Lain, Texnolyze, Princess Tutu, Rahxephon, Big O, Ghost Hound
Yoshitoshi Abe: Serial Experimetns Lain, Haibane Renmei
Masaaki Yuasa: Mind Game, The Night is Short Walk on GIrl, The Tatami Galaxy, Devilman Crybaby, keep your hands off eizouken, Lu Over the Wall, Ride Your Wave, Ping Pong, Kaiba
mamoru hosoda: Mirai, The Boy and the Beast, Wolf Children,
Mamoru Oshii: Ghost in the Shell, Angel's Egg, Jin Roh The Wolf Brigade
Keiichi Hara: Miss Hokusai, Colorful, Summer Days with Coo,
kunihiko ikuhara: Revolutionary Girl Utena, Penguindrum, most famous for sailor moon
Other Suggestions: The Count of Monte Cristo, A Country Doctor, Dennou Coil, Metropolis, Kino's Journey, Mushishi, Now and Then Here and There
Manga
Goodnight PunPun, Land of the Lustrous, Aku No Hana, Monster, Opus, Vagabond, Solanin
Anime
Isao Takahata: Grave of the Fireflies, The Tale of Princess Kaguya, Only Yesterday, Pom Poko, My Neighbors the Yamada's,
Satoshi Kon: Perfect Blue, Millenium Actress, Tokyo Godfathers, Paprika, Paranoia Agent, Memories (the short film, magnetic rose)
Chiaki Konaka: Serial Experiments Lain, Texnolyze, Princess Tutu, Rahxephon, Big O, Ghost Hound
Yoshitoshi Abe: Serial Experimetns Lain, Haibane Renmei
Masaaki Yuasa: Mind Game, The Night is Short Walk on GIrl, The Tatami Galaxy, Devilman Crybaby, keep your hands off eizouken, Lu Over the Wall, Ride Your Wave, Ping Pong, Kaiba
mamoru hosoda: Mirai, The Boy and the Beast, Wolf Children,
Mamoru Oshii: Ghost in the Shell, Angel's Egg, Jin Roh The Wolf Brigade
Keiichi Hara: Miss Hokusai, Colorful, Summer Days with Coo,
kunihiko ikuhara: Revolutionary Girl Utena, Penguindrum, most famous for sailor moon
Other Suggestions: The Count of Monte Cristo, A Country Doctor, Dennou Coil, Metropolis, Kino's Journey, Mushishi, Now and Then Here and There
Manga
Goodnight PunPun, Land of the Lustrous, Aku No Hana, Monster, Opus, Vagabond, Solanin
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