By far the game I'm most excited for is SimCity. Loved every one of the games (except Societies) and I've had a hankering for a nice city builder for years now. Hell, I've even played through some of Sierra's classics like Caesar and Zeus:Master of Olympus with Skyrim sitting on my HDD alone and unplayed.
I'm sick up to my eyeballs of shooters, first or third person variety ( Though Dishonoured looks awesome and I am looking forward for THAT. Devs from Half-Life and Deus Ex? Yes please!), or action/adventure games.
Never really got into XCOM, but I'll certainly give it a try, I'm cautiously optimistic I'll like it. Other than that not a single shred of interest for anything this E3.