You know, with the whole 3 character gameplay hook from GTA V, I keep hoping they'll do something similar for a follow up to Red Dead Redemption. The RED, The DEAD, and the UGLY or something along those lines, if you will.
Other than that, I always hold out hope that a new Dead Rising will appear even though it hasn't really been that long since the last. I absolutely adore those games for their silliness, their memorable if a little silly characters and story, as well as just the evolving gameplay that keeps adding in something new with each title. Ah well, maybe next year.