I'm probably the only one, but I'm not one to think inside the box.
I'm getting a huge Promethean: The Created vibe from this. "Murder your maker" - Prometheans are made, like Frankensteins, Golems, Mummies and such, for those who don't know. Also, you've got the missing persons, maybe being used to make another one, and the bald guy (probably a Frankenstein) is trying to use them to locate the demiurge (human creator) or other Promethean who created him, and is using the clues to track them down, out of revenge for the miserable existence Prometheans are subject to.
I find it extremely unlikely that White Wolf would have Activision make a game for this when they're busy working on an MMO, but maybe they need the funding? Also, we would have heard something from WW before now.
Still, maybe it's a similar concept, and they're going outside of WW IP on this one. It's also very likely I'm completely off. But I like to rock the boat (please, if you don't agree with me, fine, you're probably right, just don't go out of your way to tell me how wrong I am).