I'd like to see Toy Story win Best Picture. It will probably win Best Animated, and that'll be the excuse as to why it didn't win. To be honest though, I don't think it deserves to win Best Picture (it wasn't Pixar's best movie in my opinion- UP was), which isn't to say anything bad about it. I just want it to win to help champion the cause of modern western animation before the tide of sub-par western Animation and Anime crushes all the animation-starved Americans because of the ignorant views of it being "just for kids."
If I were to make a totally unbiased vote though, it'd probably be for Winter's Bone or maybe Inception. Those were the two that were most truly trying new things. Though, I'm still soured on Inception for being about dreams, but focusing mostly on a series of interchangeable gunfights when "anything is possible."
Also: While I'm sure Natalie Portman is deserving of her Oscar (I don't know, I didn't see it), I'd rather see Lawrence win, since she really made Winter's Bone come alive for me.