Not hearing what characters in-game are saying because of ambient sound, music or environmental noise.
Crap plot.
Crap voice acting.
Crap story.
Cheesy music.
Cheesy lines.
Cheesy moments.
A moment which abandons all form of logic for the sake of furthering an already logic-lacking plot.
Crashes.
Poorly implemented or unintuitive controls.
Non-responsive controllers.
Invisible walls.
Spawning enemies.
Enemies possessing improbable aiming skills.
Enemies with regenerating health.
Ridiculous learning curve.
Ridiculously hard difficulty.
Ridiculously easy difficulty.
Ridiculously unlikely moments.
Areas blocked off by suspiciously placed cars/roadblocks/rubble.
Hallways with dozens of doors but only one which is unlocked/usable.
Graphics glitches.
Physics glitches.
Game breaking glitches and bugs.
Game mechanic glitches and bugs in general.
Poorly implemented game mechanics and/or features.
Health bars.
HUDs in general.
Unrealistic game mechanics claiming to be realistic. (such as a machine gun overheating in 10 seconds, or a brand new AK-47 jamming after having put only around 100 rounds downrange.)
Bad AI.
Hardware problems.
Not seeing your own body in FPS games.
Game developers expecting all players to be 'dumber than most rocks' and leaving ridiculous tips/hints in every loading screen.
Subtitles.
Necessity of subtitles because it's hard to hear/interpret the spoken dialogue.
Being disturbed while playing.
Frame rate drops.
RROD - Need I say more?
This was the only things I could think of from of the top of my head.
BTW, does anyone even read all this?