Really, 2K/Irrational? Really? Of all the imagery from something as vivid as Columbia that could've inspired something truly amazing to look at, you end up with...essentially nothing on a box. It looks like a Call of BattleHonour cover, with its one redeeming quality being that there's at least a clear blue sky. The previous Bioshock entries had wonderful box art, hinting at an incredible world in Rapture in the background, along with provocative imagery with the Big Daddy and Little Sister in the foreground.
This just looks like Booker's wondering why he's suddenly floating 10,000 feet in the air but trying to keep cool about it.
The only thing I like about it is the burning flag; it's hinting at something, I know that much, but I can't seem to care when I can't even see a hint of what that flag is attached to. most will get Europe's contributions to Box Art, sometimes Asia's, which are by comparison infinitely better designed.