Can't say Black Isle Studios, because they're back. But they haven't released anything yet.
Cyan Worlds never went away, but they only make iPod games, so they might as well be a whole different company.
Max Design & Sunflowers, creators of the Anno series & ParaWorld. Fortunately Blue Byte still makes Anno games.
Ensemble Studios, creators of Age of Empires & Age of Mythology.
LucasArts. It should have sold everything to Telltale.
Sierra Entertainment made awesome P&C games.
Square Soft, because Square Enix really isn't the same thing.
Accolade, because I actually enjoyed Bubsy. & they didn't themselves develop the awful 3D game.
Brownie Brown: Mother/Earthbound 3, Magical Starsign, Heroes of Mana.
Borderbund: Carmen Sandiego.
Any company that made more than 1 good drop-down RPG that isn't still around today.
Cyan Worlds never went away, but they only make iPod games, so they might as well be a whole different company.
Max Design & Sunflowers, creators of the Anno series & ParaWorld. Fortunately Blue Byte still makes Anno games.
Ensemble Studios, creators of Age of Empires & Age of Mythology.
LucasArts. It should have sold everything to Telltale.
Sierra Entertainment made awesome P&C games.
Square Soft, because Square Enix really isn't the same thing.
Accolade, because I actually enjoyed Bubsy. & they didn't themselves develop the awful 3D game.
Brownie Brown: Mother/Earthbound 3, Magical Starsign, Heroes of Mana.
Borderbund: Carmen Sandiego.
Any company that made more than 1 good drop-down RPG that isn't still around today.