Epic weapons in a game.

[Zillar]

I forgot exactly what the name was, but there was a super cool weapon in Unreal Tournament that made a black hole.
Also, the MIRV from Fallout 3 (the Miss Launcher made me giggle, even though it wasn't "epic"), as well as the Gauss Rifle from Operation: Anchorage. I love that gun.

 

[Irridium]

the chainsaw from the origional DOOM.

and pretty much every weapon from the Ratchet and Clank series, every gun is unique, fun to use, and awsome!.

I also love the Blades of Chaos for God of War.

 

[AkJay]

hmm, i know everyone is going to say Portal Gun, Grav. Gun etc. so im going to go with the Nuke from Command and Conquer 3: Tiberium Wars.

 

[Irridium]

Oh, I almost forgot, the nanosuit from Crysis.

It may not be a weapon in the usual sense, but it was damn fun to use.

 

[Redphienix]

the red mushrooms in Super Mario Brothers, God these things are a life saver!

 

[bigfatcat]

ARMAGEDDON!

From the Worms Armageddon era (Worms Armageddon, World Party... I think worms2 as well)

Nothing more fun than just blowing everything up on the screen.

That game had a ton of epic weapons.

 

[COR 2000]

I will forego the obvious choices and go with the Doomsday Mt. Rushmore from Command & Conquer: Red Alert 3.

 

[SuperFelix]

The magnum in any Resident Evil game is overpowered, so therefore it is epic.

 

[yankeefan19]

I like the Spartan Laser

 

[Drolly The Escapist Monster]

The Golden Gun.

 

[Drolly The Escapist Monster]

Or Chainsaw from Evil Dead. Now nothing, NOTHING can beat that.

 

[Drolly The Escapist Monster]

And of course, the suck cannon from Ratchet and Clank, I mean come on guys, you gotta love it.

 

[51gunner]

Kinetic Strikes, AKA "Rods from God" in Endwar. It's pretty much a steel telephone pole, dropped from orbit onto a target of your choice.

It's a meteorite strike on demand.

 

[KamachoMcSagget]

The VFX from Viewtiful Joe

 

[MattyboyJ]

For me it has to be the Buster Sword from FF7, or maybe the Death Penalty in Dirge of Cerberus, that was pretty cool too.

 

[Hazy]

The Axestinguisher. You have an axe? Nice, now try wrapping some barbed wire around it. Instant awesome.

 

[rawlsku]

Sasha, Baseball bat and The Axtinguisher from TF2