Pokemon and Disgaea. Disgaea's mature, irreverent humor and surprisingly good story combined with Pokemon's gameplay and sheer awesome concept would be exactly what hardcore Pokefans like me and my friends have been waiting for all these years.
Second choice would have to be Pokemon (yes I am the type of person who watched the anime obsessively as a kid and continued to bring my GameBoy to school and play Gold every day even after all the other kids decided that nothing without blood and guts onscreen at all times could be cool, in spite of the torment, what of it good sir?) and Devil May Cry. Same irreverent humor, not as good storytelling, but without turn-based combat, and thusly better.