There's a saying that the human body is the most powerful weapon there is. Whilst a truism, there's nothing stopping one from augmenting said body like a Linux addict with a ton of spare time.
Consider the following science nerd things.
Agglomerated Carbon Nanorods (ACNR) is the hardest and strongest material humankind has yet to produce. It's like adamantium, only this stuff actually exists. Because it's so light, it can be implanted subdermally, making a bulletproof tank out of a human being without sacrificing mobility. At all.
By the time we're likely to be able to produce subdermal implants of ACNR, computer technology will have advanced at the usual tremendous rate. In a literal quantum leap, we'll be able to manipulate the technology of our own brains, adding memories that weren't there and boosting the attributes that already are with the judicious application of graphene microchips. And it's not limited to the brain. Nanotechnology and genetic engineering could make one able to tear a bus in half with one's bare hands and immune to poisoning and disease.
Genetic engineering would also combine well with the use of metamaterials - substances that can bend electromagnetic radiation around themselves, which not only make invisibility possible but could also conceivably be used to render one immune to laser weapons. If we genetically engineer the human form to the point where almost all the cells in it naturally produce an outer coating of metamaterials (save obviously for the light receptors of the eye) then the human body can become almost completely invisible on the visible spectrum.
This is all conjecture and futurology, I know. But given the choice between being a baseline, stock human female with a pump action shotgun and an unarmed human who's incredibly strong and fast thanks to the nanobots in her muscular system, possessed of a knowledge of a boatload of martial arts and preternatural reflexes thanks to the chips in her brain, is as good as immune to bullets thanks to her subdermal carbon nanotube armour plating, and is almost completely invisible to the EM spectrum and unfazed by laser weaponry thanks to her genetically-engineered metamaterial skin... I'm gonna take being the science ghost ninja any day.