Most annoying enemies in The Binding of Isaac

[Mondai Randy]

After playing for a few, decided to take a break. The most annoying enemy in my opinion is the grandfather flies... they always manage to get me somehow, and also the leapers......damn you leapers :O

share your own opinions people

 

[eggy32]

Greed heads. Fuck those guys. And those masks with the hearts. They're even worse.

 

[Aeshi]

Just about any of the "Ipeccac"-type enemies (the Green Bullets that blow up), though admittedly you can always make them off each other/open tinted rocks/secret rooms for you.

 

[DustyDrB]

Those bouncy grey things that shoot three blood bullets and take hearts and money if they hit you. Their movement is a bit unpredictable and they take a surprising amount of hits. One is not so bad, but you usually find them in groups of three. They might not kill me a lot, but I rarely get out of a room without taking a hit if those guys are there.

Things with wonky movement patterns are annoying in general. Even the odd spider will get me sometimes.

 

[StriderShinryu]

Most annoying? Easily the spiders. They're far from the deadliest, and they almost never actually end my runs, but they are just insanely annoying and frustrating with their high speed, high range erratic movement at odd angles.

Most annoying boss? The Bloat. Seriously. That bastard's the worst boss in the game and is only sort of on par with Isaac and ??? by virtue of the fact that they have more life than it does. Bloat with Isaac/??? life would be.. I can't even think of the word.

 

[Mondai Randy]

As far as bosses go, I hate Peep and Gurdy

 

[StriderShinryu]

As far as bosses go, I hate Peep and Gurdy

Gurdy's pretty simple once you've fought it a few times. Pete's probably less annoying to me now just because The Bloat is such a stupdily upgraded version of him that Pete seems neutered in comparison.

 

[Alhazred]

Aside from the ones already mentioned here, Super Globins are a royal pain. Normal Globins are basically higher-health versions of the game's standard humanoid baddies, only when they're killed the mangled remains left behind need to be killed also, else they'll just regenerate. This is balanced out by their slow speed.

Super Globins on the other hand, move like they're on steroids, meaning that you'll be far too busy fleeing the other three in the room to finish off the one you just killed. They can also take off a whole heart of life if they hit you, which they will if you have low Speed.

 

[Stevey M]

I don't think there's a particular enemy I hate, but close-confined spawns with the charging worms or suicide bombers...those don't half suck.

 

[Sable Gear]

Most annoying basic enemy imo, Clots (They big red ham-looking things). The fact that you have to precisely line up with them to actually hit them without them ducking your shots combined with the fact they fire on the horizontal/vertical with no cooldown really makes me angry, especially in the basement where they're most common.

Most annoying WoTL enemy, probably any Greed variant, but also buttlickers. I really hate them. They move too fast, take too many its and they don't "bounce" to change directions, they can redirect whenever they want, so dodging a room full of them is hard.

 

[Drop_D-Bombshell]

As far as bosses go, I hate Peep and Gurdy

Peep's posthumous version Bloat is much more annoying due to both eyes already being out and the blood shoops.

Mask and Hearts plus the eyes when they're in the corner.

 

[Rumpsteak]

The masks. The bloody masks. It doesn't help by the fact they appear in some of the most awkward room layouts.

 

[Bernzz]

I don't have Wrath of the Lamb, unfortunately, so my vote is limited to enemies in the vanilla game.

Man, fuck Clots.

Most annoying basic enemy imo, Clots (They big red ham-looking things). The fact that you have to precisely line up with them to actually hit them without them ducking your shots combined with the fact they fire on the horizontal/vertical with no cooldown really makes me angry, especially in the basement where they're most common.

This guy.

This guy knows what I mean.

 

[Henriot]

Annoying? Early on when the rolling things are in a room that has one strip to get across to the door.

Later on; the brains when you don't have wings and they spawn right next to you.

 

[Euphbug]

Anything that has to do with those masks guys and the Mask of Infamy. Without any really good items those guys are a hellish battle to be fought. Even worse those few rooms were you get 4 masks and very small moving space, pretty much a guaranteed heart or more of damage. I am just glad it has been a long time since I have seen the Mask of Infamy.

Second up, for me at least, are Leapers. Those bloody torsos that jump into space only to try to land on you and send out a quad shot of blood. They are one of the most annoying enemies by far because every once in a while they will do nothing but jump, and jump, and jump, and give no room for you offensive for a decent span of time which you will spend running in circles to dodge them all.

Last but not least by far, Greed Heads. The hanging greeds are no problem, even with the fly they are too slow to be much of a bother. But Greed Heads are evil monsters spewed forth from the bottomless pit of hell itself. They bounce so fast and if one wants to start chasing after you, you better be packing enough power to end him quick. Let us not even talk about some of the rooms they spawn in with 1 block size lanes with pits on both sides.

With those 3 hate listed enemies named I must go and finish getting platinum, with only the Purist challenge being the last block in my way.