To be fair to Origin, as long as it does what Steam does, i.e. sit in the background, manage automatic patches, save game management, and let me buy games on sale every now and again, then I'll not have a problem with it.
I don't have a problem with Steam, I don't have a problem with GFWL (except the lack of games to play on it), and I highly doubt I'll have an issue with Origin.
Yeah, it's market fragmentation, but if someone manages to come along, and compete with Steam, then chances are it'll be a good scrap.
And around ME3? Yeah, they don't do an N7 Collector's version through Origin, so while I'll be playing it through Origin, I won't be able to buy it through it.