No. Links character is male so he should remain male (or there should be some explanation as to why he suddenly turned female as well as a discovery of what that means to him) just like Zelda is a woman and therefore should remain a female character (or, in the case of gender swapping, have a quite in-depth story of why, how and what it means to the character) - zelda being an adventure game with heavy focus on puzzles and discovery rather than story would however make that quite infitting for a zelda game.
A Zelda game with zelda as the progerganist would be fine though (and would lead the main character to be female) just like letting the player play as ganon or any other character in the franchise would be.
A Zelda game with zelda as the progerganist would be fine though (and would lead the main character to be female) just like letting the player play as ganon or any other character in the franchise would be.