I would play it because the gender doesn't matter. If you put a female in the very same role, she is symbolically male anyhow. Thus the change would be pointless as the story is not crafted around the notion of gender so much as it is around an archetype.
If you want to know why females in AAA games tend to be "21 year old bikini models with something to prove", that's because that's exactly what happens when you make a female symbolically male. AAA games are constructed using various tropes and trappings that imply the character is male. Simply gender swapping is a shallow attempt at hiding the obvious in this case. The better question is why don't you find publishers willing to risk tens of millions of dollars on a game and story built from the ground up for a female protagonist?
The difference between the hero's journey and the heroine's journey are small but important. Fundamentally, the difference between the two is that the heroine's journey is rife with conflict between masculine and feminine and the turning point in the story is the heroine's becoming a goddess and the conclusion is found when the rift between masculine and feminine is healed. There are a thousand excellent stories to be told using the less familiar heroine's journey variation of the monomyth, but these stories are not likely to generate exciting set pieces that can be lifted for a promo reel.
To put it another way, consider a few big games of the last several years. Mass Effect allowed you to play the game as a male or female but in the end did choice of gender really impact anything in the story? Perhaps a few reactions here and there. In effect, switching genders simply altered the set of potential romantic partners and even then they were largely interchangeable as far as notable beats in the story go. Or Skyrim - gender doesn't matter in the slightest beyond base cosmetics. You are treated no differently, and the only stat that changes is a tiny alteration in movement speed (with the males being insignificantly faster). Simply swapping genders in this case does not make the game a story about a female - it's a story about a hero who just happens to be female.
In my view, there difference there is notable.