Depends on the Friend and Family member in question. Also, what is the causing this loss? [Ie, why the decision]. I would rather loose my grandparents, to any friends. However, I could not choose my friends over my sister[I hate her sometimes, but I love her really], or my parents. As much as I love my friends, I love my family too, and my family will always be there for me. I only have 3 friends that I'm really close too atm, and I'm currently crushing on one of those, so could be an interesting choice if I had to choose between saving them.