A fist fight with my most recent Shadowrun Dragonfall character? Well, she's a physical adept (should've stuck with magician!), so punching is kinda her thing. On the other hand, she routinely misses on attacks at 88% hit rate or higher...
She'd win in a fight trivially, of course, but she's also kinda a saint as far as the average runner goes. We'd have little in common, but no reason to fight. Might ask if she offered magical kung fu lessons.