BFG, natch
Drunk Missile (ROTT)
Chainsword (Warhammer)
Quake rocket/grenade launcher
GTA Rocket launcher ( / tank)
Duke's shotgun
The micro nukes from (insert name of favourite 2D Apogee platformer here) e.g. DN, Halloween Harry, Keen...
And, well, how can we ignore the Sheep, Dynamite, Blowtorch, Shotgun (into water/crates/friend who'll take critical damage from it) or of course the ever so mighty PROD (see: shotgun) from Worms?
I can't respect Cloud, BTW. Dude's obviously compensating for something with that thing. No-one in-world can possibly be impressed. Probably all laughing behind his back and making cute gestures with their pinkie.