Suicide, sex and death, all things that have happened in Spider-Man. All things that have happened a lot actually. I'm going to make a short, one-example list of each of those that no one will fucking read:
Suicide: After the trauma of dealing with Venom's symbiote Anne Weying (ex-wife of Eddie Brock) is left traumatized and throws herself out of her own appartment window right in front of her ex-husband and Spider-Man, causing her to die.
Death: Let's just lead with the best example, Death of Gwen Stacey; During a battle with the Green Goblin she is throw off the bridge, Spider-Man shoots down a webline to save her only to have the webline result in wiplash, thus snapping his own girlfriend's neck.
Sex: Most fun example; in the most recent issues you see the immediate aftermath of his many, many, MANY sexual exploits with the black cat, not to mention they're always running off to fuck eachother again (well, he's got a GF again now, so that's over now, but still).
EDIT: Also, that song and dance linked; that was fucking attrocious, what was all that shit they added? The goblin doesn't look like that (in ANY of his iterations) and with the exception of Kraven and Electro (SPARKLERS! WOOOO!) those are not the members of the mother fucking sinister six! Hell, what the fuck was with those made up retardations with the bees and the knife dress? Putting aside the dumping on the source materiel, the dancers were often out of sync and a few didn't seem to know what the fuck they were doing.