I can't really relate. Many of my favorite games of all time have been isometric. Turn-based strategy and RPGs. We're talking XCOM(original and remake), we're talking Fallout 1&2, we're talking Jagged Alliance 1&2, we're talking Baldurs Gate 1&2, and so on, and so on.
It just might not be the best for single-character action gameplay, well, melee it's still good for melee games like Batman: Arkham City, ok so I guess it's bad for single-character ranged action gameplay... well, unless you consider over-the-shoulder like Borderlands to be isometric...
The perspective I've loathed for a long time(but recently started to relent a little, I liked Terraria, and been trying some others, with mixed results), is side-on 2D, especially platformers. Probably because I hated platforming, and I feel more restricted in side-on than isometric.
You can have isometric games that let you get verticality, jumping, ladders, etc. You can't really go around stuff in a 2D side perspective, all you have is forward, backward, up and down, so usually just forward and backward really. Which for example made me hate Zelda 2 way back when, despite liking the first one, and loving the third one.
Are 2D side-view games "background, the game"?