Alright, you want me to put some thought into this one? Here goes.
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The Escapist Video Game
This is an action-adventure-RPG type game which will probably be multi-system and on PC, but - and we cannot stress this enough - not on the Wii.
The narrator would, of course, be Yahtzee (Paid by the flipping word, the bastard.), who would move along the story and, in fact, defy recapping chapters by poking fun at the player for not keeping track of his own story.
You play as you, and by that I mean your Escapist persona. So, in this case, this would be the adventures of F A L L O U T J A C K, the wise-cracking and Deadpool-worshipping know-it-all donning the Enclave armor. (Rumor has it that Jack resembles Johnny The Homicidal Maniac under his armor, though.) And before you say "Oh no, this is going to turn into an FPS between a bunch of armored lunatics!", this will not. The point of Yahtzee as the narrator is to prevent this from happening.
Additionally, there will be commentary from the cast of Unskippable, and the Loading-Ready-Run team will be all town-related NPCs, all of whom are having different philosophical discussions about being an NPC. Things like "How strange it is that I am rooted to the spot and unable to go and do things like a normal person.". Of course, naturally, they will function AS NPCs, but in a breaking-the-fourth-wall way.
The Story, as told by Yahtzee, was that with the onset of constant trolling becoming a serious issue in the Escapist forums, The Powers That Be decided to pull out their greatest artifact - only, we don't know what the hell it IS (Trade secret.) - to transform every member and indeed the entire site into some form of video game. From there, they would cull the herd in a permanent-like fashion that no law in the world DARE convict them. Unfortunately, many regular Escapist patrons - like our bloody-minded hero - object to this, especially once the meglomania sets into the staff of the forums. Yes, a dream come true for any forum-goer: The staff are evil and you must defeat them.
Of course, this is no easy task. Because while the staff cannot simply ban you anymore, they can certainly KILL YOU. This is especially a problem when it turns out that the Ban-Hammer is a device weighing 82 tons and flung via a Starcraft 2 Thor mecha. This game is one that is taking the piss, but doing so in a hilarious fashion. For even though there is a definite karma system in place, there are definite cases of "You're an asshole, but we love you for all the good you've done.". That is, unless you keep shooting the NPCs and realize that when they attack you...they have infinite HP!
Weapons can be anything. Armor can be anything, assuming you were unarmored. Citing Tv Tropes creates a black hole to suck in targets FOREVER. Trolling floods the area with snarky green guys, creating havoc, though this probably attracts the attention of a high-powered Mod-Reaper. Fire guns, use Personas, unleash the Order of the Stick from a Poke-Ball, GO NUTS! Oh, and bad grammar? IT KILLS INSTANTLY, but then you're inexplicably being tortured by Nazis.
Journey through the Escapist land and gain untold powers to do battle with the staff and retrieve their unnamed MacGuffin to restore everything back to 'normal' (Or not! Become a god if you like too, but remember that the sequel will use that against you!).
Also, stick around after the ending credits for a special episode of Zero Punctuation, critiquing the game you just played in the usual fashion.
