I'm actually really looking forward to the upcoming Tomb Raider. I can remember buying Tomb Raider Anniversary on the PlayStation 2, and loving every minute of it. The shooting, the climbing, the puzzle-solving... Mmmm. And the new one looks intriguing. Plus, it was written by Rhianna Pratchett, and I absolutely adore her father's Discworld novels, so I'll be interested to see how well she does. I know she worked on Overlord and Heavenly Sword, but I don't know just how much of the writing of both games (though in the case of the former, there isn't really much writing to speak of) she actually did. Now she's in the driver's seat. Pretty excited.
Aside from that, The Last of Us looks really good, and of course, there's Bioshock Infinite. Also, now that Del Toro's Insane is back in development, I'm really looking forward to that as well. I'd also mention The Last Guardian, but I have no idea at this point whether or not it will see the light of day.