Legend of Zelda: Ocarina of Time. I couldn't give you an exact count, but every few years I pick it up and play it again. I also try to run through Majora's Mask, Wind Waker, and Twilight Princess in the same gaming binge (I have the Gamecube versions of all four games).
Lately I've been more and more inclined to pick up Zelda again. I'm thinking I'll tell her, "Hey baby, whoever gave you that Triforce of Wisdom should have put in the effort to get you the whole set. I would have." (yeah, I don't do pick-up lines)
In all seriousness, I want to go back to playing those games again, especially because I can't stop listening to this guy's rock medleys.
Last time I was playing, I went through Masterquest and stopped in the middle of Stone Tower temple.
...that's it. When I get home from work, I'm going to go back and kick Twinmold's asses.