Real attempts to push the superpowered genre forward. New weapons that work in new ways, not just new skins on the same guns we've all used forever.
But most of all, I feel like we have all of this incredible tech, but no one has tried to outdo Red Faction's basic concept of environmental destruction. All games that have it, have some bland version of "destructibility". Where is the 'Witcher 3' of destructibility? Or FPS spell slinging? Or something to finally unseat Spider Man 2's city traversal? How about Hulk's bounding movement, or sliding on crushed cars?
All of the games that had crazy, fun, and new elements seem to have been replaced by attempts to refine the same handful of accepted formulae. Bullet Storm, Phantom Dust, Prototype (a testament to good ideas executed to meh), all went away. inFamous gets a release every 4 or 5 years at best, along with Crackdown, but Assassin's Creed was there twice a year?!
And finally, and most of all... Freespace. Wing Commander. That at least, seems like it might be on the verge of a comeback.