The only Reason that Mass Effect 3 could fail would be due to Origin Requirement. If its in there, i wouldnt buy it. Doesnt mean the Game fails though, just means i wont be buying it personally. However after seeing that they made the first two Games very good, granted maybe not the Holy Grail many expected but still very good Games, i doubt the third Installment would fail in that regard. It will still be a good Game.
Saints Row 3, well what i have seen of it, its basicly Saints Row 2 turned up to eleven. So since i liked the second one alot, and as long as the third one wont have as weird Issues with Hardware Hunger, i doubt it will fail at all. The only thing they could do is basicly go so crazy that it gets utterly ridiculous, but even if that happens you can still play it and just laugh at how ridiculous it is.
Not interested in the other Games personally. I might get Skyrim in case ME3 has the Origin requirement, but other than that, i dont really see a Reason to get any of the Games that will be coming relatively soon.