Here's the thing, Comics for the most part suck. They're terribly written, crunched out by a few writers under pressure to do the super hero equivalent of a Soap Opera, just dramatic moment and dramatic moment, and every 3 years everything is rebooted/erased/moved-to-a-new-earth to undo the last writer's flails. Think of comic books like Dragon Ball Z, except instead of dragon balls and reincarnation, every time a character comes back to life or gets a new power the writers create an entire alternate timeline with entirely different characters, backstories, motivations and plots, all to explain why Vegeta is allergic to Broccoli for an episode.
And like soap operas made into movies, unless heavily edited, they fail. See we don't have 400 issues, 80,000 words, and 20 years to establish the Ventriloquist. We have 120mins, 130 with the DVD extras, and about 26.7 for Mr. Wesker.
So my answer is always ANY OF THEM. Fuck, take any single villain, change 70% of him to be movie friendly and it will be great.
Here, Batfleck Batman vs. Daniel Radcliffe as the Riddler, where Edward was meant to be a info-guru for Bruce but while tracking the Joker and other villains became obsessed with the criminal mind(maybe after his best friend, which-ever Robin it is, was killed by Joker) and came to realization you can either kill them or join them, but holds to a strict no direct killing ethic. So he creates riddles for everyone, Gotham, Joker, Two-Face, Batman, everyone. Think Saw, but instead of morality, its a riddle, and instead of Becky the Cheerleader its Mad-Hatter, Bat-girl and Steve the taxi-driver trapped in a leaking bank car with...I dunno, the Sphinx riddle on the walls.
So everyone is on a even-footing for riddles from this genius if disturbed and out-of-control vigilante, who Batman is willing if hesitant to take down because he still believes there is sanity in Edward and he, Batman, was the one who opened Pandora's Box, and maybe, just maybe, he can save Edward.
Its an alternative take, but for a movie it'd work.