God, so many that have already been mentioned, I don't know what to add...
MegaMan X9
MegaMan Legends 3
Psychonauts 2
Suikoden 6
Dark Cloud 3
A New .hack Trilogy (Hey, they made massive improvements with G.U. I'm interested to see where they can go with the current gen's capabilities)
Breath of Fire 5 (or 6, if you count Dragon Quarter or whatever it was called)
Actually, a Dragon-focused video game that doesn't suck would be nice. I played Dragonrage and Drakan for the PS2 and got bored with both fairly quickly, and though I haven't played it, the last thing I heard from Lair was that it didn't meet expectations. Just once I want a game where you play as a dragon, but it doesn't devolve to some simple flight sim/burn everything to the ground game.