Susan Arendt said:
I think referring to grenades as "nades" has to stop, personally.
This. Also, that entire post is opinions. In my opinion, Uncharted is based around fluid control, and having all your options at the touch of a button is a core of the series. You don't have a weapon wheel, and you don't switch to grenades.
Also, whenever they're throwing the grenade at you (during which time they aren't shooting you) to kill them. If they try and cook the grenade, you can kill them easily. If they don't, you can finish killing them and still have time to roll away, if the barely aimed and small blast radius grenade even comes close to injuring you in the first place.
Similarly, regenerating health is key to the fluid control of the series. No tedious "where the fuck are the health packs?", no backtracking to look for one you may have seen ten minutes ago. Ditto for multiplayer, where I prefer regenerating health in everything except ultra-realistic simulation type games, or maybe the occasional class based game. Of course, this is all my opinion.