I read an interview with him at one point. He said there IS a meaning, and that some people emailed him and understood it, and that made him glad. But he didn't want to explain what it was or anything.
Yes, this is a strange attitude. It's either open to interpretation, or it means something. If it's the former, then open discussion should be welcomed without declaring people to be "wrong". If it's the latter, and people don't "get it", then you've failed to communicate your ideas and you're just wanking.
His Wikipedia page has some choice quotes about the need for designers to make more "ethical" games.
http://en.wikipedia.org/wiki/Jonathan_Blow
I hope he hits it big. I could make a comic from just about everything that comes out of his mouth. He's just not famous enough for me to get away with it yet.