1) You are completely invincible to damage until your last hit point, upon losing said hit point your life-force decays and you explode into a million chunky pieces (or fall down, whatever, its cool.) Several games.
2) You're safe as long as you're under control of a player, however, the moment a cutscene starts you're vulnerable to capture, sudden death and torture even at the hands of a group of pathetic losers you slaughtered hundreds of just one level ago. Metal Gear Solid
3) No one will ever comment on your dress sense (or lack of it.) Except in Fable that is. Oblivion 4, Fallout 3.
4) Medikits heal everything. UNLESS you're on the opposite side of the heroes, upon which they become useless. Numerous FPS's
5) Plasma is good against shielding, bullets rend flesh. Don't mix them up. Halo games.
6) If your car is upside down, keep your distance. Regardless of its condition beforehand, it WILL explode. Said car explosion will also inevitably lead to other vehicles exploding nearby. This often has unforseen and unfortunate consequences. GTA, of course
7) If you're not a nice person, and nice people you're fighting get really, really pissed off about something and start to glow a funny colour, run like hell! Final Fantasy 7-9
8) No matter how antiquated they are in comparison to current technology, you must always use a sword if one is available: Halo 2 and 3, especially true of Final Fantasy 7 and 8.
9) Don't worry if you're outnumbered a hundred to one. The strength of your enemy is inversely proportional to their numbers. So divide and conquer. Its when only one enemy confronts you that you should be worried. The same applies to your team. Numerous games, especially blatant examples are Metal Gear Solid, Assassins Creed, Lost Oddyssey.
10) Regardless of how overwhelmingly powerful your final opponent is, no disadvantage cannot be overcome if you fight hundreds of weaker enemies beforehand. Maybe you absorb their fung ku or something. Several RPG's.
11) People can, believe it or not, survive having meteors thrown at them, getting riddled with bullets, having grenades go off at their feet, getting thrown hundreds of feet into the air, and the like, as long as they're really badass and haven't had it done too many times. too many games to count, RPG's are the worst offenders, shoot-em-ups take a close second.
12) You will never, ever get out of breath if you are trying to save the world. This magically bestows you with the ability to jog for miles, never sleep (unless wounded) and fight hundreds of people, with injuries, without ever even breaking a sweat, unless of course the player is no longer in control and you fall victim to a cutscene. Various games.
13) You must always take the sword of plot advancement. Even if taking said sword will really screw things up. Legend of Zelda
14) If there is a princess in your world, she WILL get kidnapped... occasionally from her kidnappers. It is only a matter of time. The people chosen to save her are usually either pre-teens, criminals, or plumbers, though a certain blue hedgehog has also been known to engage in this activity, usually demanding payment in rings. Legend of Zelda, Final Fantasy 9, Mario games, Sonic 06.