You're saying it as it's on my mind. I really enjoyed Mass Effect 2 as a "Gears of War with meaning" kind of thing, and if anything gameplay-wise, ME2 shows pretty damn clear what all these fixed ideas of genres in our heads are worth, which is nothing at all. Here we have an RPG that is stripped of most of the things that make up an RPG by conventional wisdom (excessive leveling, looting, boring combat), but is more of an RPG than I've seen ever. Because it really puts the "role playing" into RPG: When I play Mass Effect (be it 1 or 2), I am Alice Shepard (which happens to be the most carefully crafted She-Shep there is, mind you).
That isn't to say that ME2 is perfect, though. In quite a few aspects, some of them dear to my heart (overall plot and its indulgence in blatant gameplay-story segregation in the already disappointingly meaningless finale), it really drops the ball. But this one - this one it got right.