An old family friend was actually born with no pupils in his eyes. (Not with extremely enlarged pupils, none at all.) He had to have holes punched into his eyes as a child so he wouldn't be blind. Apparently it was an extremely new surgery at the time, and very risky, but it worked and he can now see, even though his pupils are slightly off-center.
So yeah, it is possible in real life. But they probably go with it in anime/whatever for symbolic and stylistic purposes rather than realistic ones.
So yeah, it is possible in real life. But they probably go with it in anime/whatever for symbolic and stylistic purposes rather than realistic ones.