I personally like the unique names. It gives them a chance to stand out in a crowed unlike when someone yells "Brittany" or "Matthew" and 10 heads pop up (In my grade 8 class, there where 6 Brittany's and 3 Matthew's...) So I say go for it.
Sure some people pick some very, very strange names, but as long as you DO put some thought into what could be a potential for easy harassment, all should be good to go. As many have mentioned, if kid's are determined, ANY name can be turned into a nasty slur. Lyra kind of reminds me of Laura, but different enough to stand out. Maes does sound awfully close to Maise, the French word for corn, but it's got a distinctive ring to it. I suppose it also depends on what you've given as a middle name(s) if any. Initials count too Mine are NHL, so I got a bit lucky there being a hockey fan! Someone in my family is Mychelle Linn, and my sister's best friend is Acasa Beers (No middle name)....
IF I ever where to bear children, my now ex and I had discussed names and some we came up with where unique in there own way, but depending on context could be warped. I prefer odd spellings of anything, but combine the two and you can get some really odd ones. Here's a list of some of the better ones we had (That I can remember). We tried to have some unique spelling, but we tried to keep it tame as if we had kids, they would be able to pronounce/spell them at some point before schooling. We also tried to go a bit semi-normal with some so that the kid would not be "too odd".
Boys:
Archturis Desmond or Desmond Archturuis, Kurda Joseph, Dakota Meyles (May-ells),
Girls:
Evanna Ane-Mayre, Tabitha Makenzie, Hecayte Jennifer or Jennifer Hecayte and Helaina Morigan.
Besides, it's also a big trend now, in recent years, it seems a lot of parents are opting for some less-traditional names, and it's not just whacked-out celebs..