I would recommend Spice and Wolf.
From TvTropes:
Lawrence, a traveling merchant, accidentally frees the local harvest god, a centuries-old giant wolf named Holo who takes the form of a young girl. She convinces him to let her travel with him and seek out her dimly-remembered homeland.
Interestingly, the main thrust of the anime is centered more on the business of Lawrence than on Holo's supernatural nature. While her good senses and intellect come into play reasonably often, she is treated as a companion of Lawrence rather than the focus of the show. Instead of action or fanservice, Spice and Wolf is far more likely to focus on an in-depth discussion on the currency exchange market, with no notable attempt to make it more interesting by going over the top. Surprisingly, the show does this rather well using character interaction (mostly between Lawrence and Holo) and business intrigue.
It's really a sweet anime and definitely worth a look.