Anyone else out there not really get hangovers?

[Hunter65416]

The only time I ever really felt sick after drinking was a time I drank most of a bottle of Jack Daniels, If I drink A 10 pk of JD and Cola or whatever the worst I ever get is a dry mouth in the morning, My advice is to drink water in between, but I dont know if that works for most people. There is a history of alcoholics in the family, maybe thats why.

 

[Henrik Knudsen]

I almost never get hangovers, why?

I have quite a walk home from where I usually drink (downtown), I almost always walk home. It sets the blood flow in motion and (arghhgt I can't explain it). Anyway exercise is the best medicine against headaches and hangovers.

Btw sex is exercise, remember that next time that is an excuse...

 

[Boris Goodenough]

I have two friends who also don't get sick, which most likely means they have a hyperactive enzyme aldehyde dehydrogenase. Sadly that is a prime factor in determening wether people will become alcoholics or not.

Basicly the pathway is Ethanol -> Acetaldehyde -> Acetic acid, where Acetaldehyde is the most poisonous part of the pathway.
Aldehyde dehydrogenase does the last part of the pathway, namely Acetaldehyde -> Acetic acid. Alcohol dehydrogenase does the first part Ethanol -> Acetaldehyde. Each step is an oxidation.

Methanol undergoes the same oxidation with the same two enzymes. Methanol is very dangerous, 4 grammes is enough to end us, less can make us blind. It is not methanol itself that does it but the next oxidation step, into formaldehyde which is VERY dangerous as it binds to tissue and thus "destroys" it.
Methanol is exists in the range of around 4-35 grammes/litre in spirits, vodka with the lowest and cognac and whisk(e)y with the highest, it's part of the taste.

The reason we don't die from drinking spirits with methanol in them is that ethanol out competes methanol for the active site (where the oxidation happens) on aldehyde dehydrogenase which means we don't get as much formadehyde in our blood/organs. However it is still toxic so that is why people without hyperactive aldehyde dehydrogenase get headaches (primarely, the other reason being dehydration of the brain, so drink lots of water before you go to bed).

 

[wintercoat]

Well, I'd have to get drunk first, now wouldn't I? Having never been drunk, even after drinking a rather large bottle of brandy plus some, I guess you could say that no, I don't get hangovers.

 

[Korolev]

I have two friends who also don't get sick, which most likely means they have a hyperactive enzyme aldehyde dehydrogenase. Sadly that is a prime factor in determening wether people will become alcoholics or not.

Basicly the pathway is Ethanol -> Acetaldehyde -> Acetic acid, where Acetaldehyde is the most poisonous part of the pathway.
Aldehyde dehydrogenase does the last part of the pathway, namely Acetaldehyde -> Acetic acid. Alcohol dehydrogenase does the first part Ethanol -> Acetaldehyde. Each step is an oxidation.

Methanol undergoes the same oxidation with the same two enzymes. Methanol is very dangerous, 4 grammes is enough to end us, less can make us blind. It is not methanol itself that does it but the next oxidation step, into formaldehyde which is VERY dangerous as it binds to tissue and thus "destroys" it.
Methanol is exists in the range of around 4-35 grammes/litre in spirits, vodka with the lowest and cognac and whisk(e)y with the highest, it's part of the taste.

The reason we don't die from drinking spirits with methanol in them is that ethanol out competes methanol for the active site (where the oxidation happens) on aldehyde dehydrogenase which means we don't get as much formadehyde in our blood/organs. However it is still toxic so that is why people without hyperactive aldehyde dehydrogenase get headaches (primarely, the other reason being dehydration of the brain, so drink lots of water before you go to bed).

Fellow Med Student by any chance? Or Doctor? Anyway, it was nice reading this forum post as I have exams on Friday and this has helped me revise a bit of my liver pathology.

And you're absolutely right - one of the key indicators for future alcohol abuse is early alcohol tolerance. That, and the age the individual starts drinking.

 

[Queen Michael]

I've never been drunk. And I never drink alcohol. Mostly so I can be smug about it, to be honest. So nope, I never get hangovers.

 

[hazabaza1]

I've only drank a few times but not enough to get a hangover. Even one time when my dad said I'd regret it in the morning I was fine, but I'm still probably not the best person to ask.

 

[Bertylicious]

Sometimes the hangover is the best bit. Usually when someone brings you a bacon & egg sandwich.

 

[Angie7F]

It has to do with your genes.

I try to prevent it by eating before I drink.
I also heard that vitamins and water help.
And turmeric.

 

[Dark Knifer]

I usually drink water and eat food as I drink so hangovers haven't been a problem for me.

I've only thrown up once from drinking and that was my first time with straight vodka and after I threw up I felt right as rain, no hangover.

 

[Foolery]

Yeah. I rarely drink, though I could potentially drink like a fish and be fine. I'm more concerned with hereditary cancer genes than alcoholism.

 

[JoJo]

I've never had a hangover, despite drinking copiously on many occasions. I think this is because I'm a relative lightweight, it doesn't take much alcohol to get me drunk but I'll also process that alcohol very fast and often sober up in a couple of hours if I stop drinking.

 

[SpAc3man]

Well a hangover is mainly the dehydration from your body using a lot of water to process the alcohol out of your body. Drinking water in between drinks or having a large drink of water before you go to sleep will pretty much eliminate most potential hangovers.

Hangovers can also be enhanced from the presence of other substances that can be produced in the production of alcohol. Various organic compounds such as aldehydes and ketones, even in small concentrations, will make a hangover worse.

This brings me to your drink of choice. Jack Daniels. JD is a distilled and filtered spirit. The process of making most mass produced spirits like this makes the drink rather pure compared to non distilled beverages. I can guarantee I could get you hungover with my homebrewed beer.

Also you are 19. Three years ago when I was your age I was seemingly immune to anything more than a bit of morning dehydration and lack of energy. Granted I was not brewing then.
A bottle of Mizone and a can of V cure any hangover so it doesn't really bother me at all.

 

[Vicarious Reality]

Practically never got hangovers when i practically drank half a bottle o vodka every day
Occasionally woke up drunk, but that does not count does it

Wine on the other hand, gahhhh damn that juice is nasty... yet strangely compelling sometimes
Disgusting substance for so many reasons

 

[Casual Shinji]

I'm one of those boring doofuses who doesn't drink at all and has never been drunk once.

So no hangovers, just that sickly feeling you get when eating too much chocolate.

 

[Poetic Nova]

It takes alot to gett me truelly drunk, never had a hangover either.

 

[Euryalus]

Not unless I go really hard no, not as far as I can tell... Though I often wake up with mild headaches when I haven't anything to drink anyway so who knows XD

No Nausea or other miserables things though, so its probably just my head being stupid.

 

[Pebblig]

I just don't drink, tends to be that 2-3 beers will make me considerably tipsy, and 5 beers will make me very drunk and will result in a hangover. I've only ever been hungover twice, the first time I said never again, and after the second time I've actually stuck to it haha.

The reason I now don't drink (other than the odd cider every few months) is that I seem to get a headache now when I drink anything alcoholic, like almost an instant hangover headache about an hour after drinking it. So now I just stay clear of the stuff.