Meh, my first reaction is to to actually start screaming about the DLC already being planned and hyped for a game that isn't even out yet. This is the kind of thing that enrages me about the industry.
As far as the idea of having George Washington as a bad guy, well it's not like it hasn't been done before. They kind of ran with the idea of him being a ghoul/cannibal for the movie "The Washingtonians" (it's on Netflix I believe).
It's doubtful there will be a fox news/right wing outcry since alternative history has been done so many times before accross a wide spectrum of sources. Guys like Harry Turtledove or George R.R. Martin (for what was done with more recent history in "Wild Cards") would have gotten huge amounts of flak if it was going to be an issue, and with no offense to Ubisoft or Assasin's Creed fans, I doubt this will be around as long or have the enduring fanbase (over decades) that certain other alternative history creators have enjoyed.
The only bit that's dubious about it is the timing. Right now I'm a bit more sensitive to US bashing than I have been in the past, in part because of the demands that the US not "belittle or disrepect" other cultures and their history, which we pay a lot of attention to. We've taken France to the cleaners on a lot of levels in the creative media, so turn about would normally be fair play, but right now with Halloween approaching and people getting all upset about "offensive" or "insensitive" costumes via that whole "it's a culture, not a costume" thing, my tolerance is somewhat limited.
I guess what I'm saying is that when Victoria's Secret gets backlash for selling Geisha themed Lingerie:
http://www.huffingtonpost.com/2012/09/24/victorias-secret-geisha-outfit-photos_n_1909366.html
Geisha's being, all romantisism aside, high class escorts (yes they can do more than have sex, but so do a lot of hookers nowadays, as you find out in a lot of those exposes on the brothel industry in Vegas and such...
It gets my goat a bit when people think dissing George Washington is something to let go. I mean even in the worst case scenario my basic attitude is that if we're going to let other cultures do this kind of thing (as was mentioned, Ubisoft is French), then we shouldn't take it seriously and start boycotts/pressure and tolerate people creating platforms over crap like Geisha Lingerie, or someone wanting to dress in an iconic fashion of someone from another country for Halloween or whatever.
In the end though I guess you could say I'm more irritated with the left wing, than I am with the people actually creating things like this. I also mean "irritated" as it sounds, it's not something I think needs to be stopped, or think is that big deal... it's just an irksome dual standard that comes from political correctness, where the US can be ranked on and see things like this done without any problems (or kudos) but it's a bad thing for Americans to do the same thing.... in my mind everyone is fair game (so to speak).