I expect either Iron Man or Spidey to say "What the hell are you smiling at?" How this goes depends on how long it takes the heroes to find the weak spots and who's involved. The more heavy hitters like Iron Man, Thor, Wolverine, The X-Men, Fantastic Four, and maybe Dr. Strange could waste these freaks no problem. It would look cool for Falcon, as the newest Captain America, to flay round and throw the shield into the backs of their necks.
Spider-Man, however, would ANGST over having to kill them, seeing as that's his thing and by this point basically every superhero in Marvel has killed something already. On a side note, that makes the Punisher sound redundant.