Best Bad Guy!

[malestrithe]

Dahlia Gillespie. She was the reason for the craziness in the original Silent Hill.

Bob the Goldfish.

Mike Tyson. Even if you remember his pattern, he still kicks your ass.

Goro. Still the best claymation villain in the Mortal Kombat universe.

 

[metacree]

Freiza, best villan ever.

 

[Stevanchez]

Darth Vader and Tyler Durden(Not really sure that counts because he was technically the protagonist also)

 

[theodin77]

Luca Blight
The only video game villian that I know of where the hero just wasn't strong enough to kill him.
Cloud has owned Sephiroth many a time, but it took a freaking army and then some to kill this SOB.