I can easily sum up my feelings toward Bioshock Infinite in two words:
Fuck yes.
Everything I have seen so far suggests they're taking the things that made Bioshock awesome and throwing it into a (mostly) new setting with completely new story and characters.
I mean, come on, it's set on a flying steampunk-ish city intended as a symbol of American exceptionalism. And it has a giant gasmasked bird golem who has a Stockholm-syndrome-ish relationship with one of the main characters. How often does one get to say those things about any game, let alone a shooter?
Also, those skyline things look like good fun. [http://www.youtube.com/watch?v=4XYPgH_HFCU]
The one feature I'm not so enthusiastic about is that 'tears' business [http://www.escapistmagazine.com/videos/view/trailers/3596-Bioshock-Infinite-Windows-Into-Other-Worlds-Trailer]. (That's 'tear' as in present tense of 'torn', not the thing that comes out of your eyes when you cry.) It doesn't look bad exactly, just kind of gimmicky. They basically just letting as choose which of several items to spawn. Although the trailers strongly suggest that it will be part of the story, so I guess there's still hope.
So yeah, lookin' damn good overall.