Ed, Edd, n' Eddy easily. The (Earlier) Simpsons, Futurama, and King of the Hill.
And let's not forget everyone's favorite, purple, scared little pansy: Courage the Cowardly Dog.
[sub]Though it scared me half to death when I was younger.[/sub]
On an Anime front: Cowboy Bebop, Samurai Champloo, Death Note, NGE, and Paranoia Agent. Each respectively awesome in their own merits, though Bebop blends Americana Jazz and a futuristic setting perfectly.
While Champloo (Created by the same man behind Bebop) is the exact opposite. Sporting a setting of Fedual Japan and a 'Champloo' (Or mix, if you will) with new age hip hop.