I think they should make it so only those who have never played "Portal" are allowed to take the class, so they ummm... have no preconceived notions.
At the beginning of that section of class, the professor should come in and eat delicious cake in front of the class while they work hard, and promise when this portion of the lesson plan is done everyone will get some. Each time the class meets he should put down delicious cakes and munch on it, while making promises that everyone can have some when it's done.
Then of course predictably at the end of this part of the lesson (however many classes it takes) tell them it was all a lie and keep eating cake in front of them.
I mean after all, going by the cinematics GlaDOS did indeed have a cake, she just didn't share which makes her doubly evil.
That and anyone who says that they like pie better should automatically fail! (muhwahahahaha!)
Sadly, the above is the closest you can come to actually educating them on the game and it's treatment of delicious cake. I doubt the university would allow the professor to gas the people in class after they play the game, put them in crippling leg braces, and make them navigate a gauntlet of "SAW" and "Cube" inspired traps under the school with red and blue colored flashlights with no use given the lack of real portal gun technology. Sort of a way of getting people to understand the human condition of experiencing death traps with no hope... and well... okay, okay I'm getting crazy even for me.
Still, if some university wants to give me Tenure and a large budget to design my own classes, just let me know. I've got this great idea for a class that will use both "Battle Royale" and "Team Fortress 2" for inspiration. When done graduates will have a better understanding of insanity, sadism, and the artistic merits of blood splatters!