I don't think the podcat has every gone that far off the rails before...
If you want to get into Deadpool, there are a few options:
A. The best recent run was Deadpool & Cable in the 2000's. That had a healthy mix of balancing the clown part of his personality with a few human moments, but has the odd dated references.
B. There was a 63 issue run of Deadpool by Daniel Way. It was a mixed bag of stories that tied up quite nicely. However, since it starts in the middle of the Skrull secret invasion it would require some wider back-story reading.
C. The series was reset again in 2012. I haven't read any of the 18 issues released so far, but it would be a good possible entry point.
D. One-shots. For example Deadpool: Merc with a mouth, where Deadpool teams up with his zombified head from an alternative universe.