Male Shepard/Miranda Lawson. They have an amazing love/hate relationship. The attraction between them almost burned my PC. The most badass romantic duo EVER. The badass hot-head/the cold *****. I have no idea how you can choose any other romance. The sexual tension between them is painfully obvious. Whenever I imagine the innocent, awkward Tali next to my Shepard, I fall off my chair from laughing.
Max Payne/Mona Sax. Tragic, fatal and unquestionably amazing. Those two complete and break each other at the same time.
Nathan Drake/Chloe Frazer. Oh god, I hate Elen. Drake/Chloe for the goddamn win. They can't have a normal conversation for two minutes without throwing in a sexual innuendo. How can you not love that?
Male Grey Warden/Morrigan. Those two were attracted to each other from the very start. The bastard and the *****. Goddamit, Morrigan, I WILL find you.