favorite mass effect quote

[Vrex360]

Ashley Williams: That puts a whole new spin on the phrase "drop on the floor and give me twenty".
Commander Shepard: You still sassin' me soldier? I think you need more physical training.
Ashley Williams: Tsk. Now, skipper, what will it take to prove I'm in prime condition?

Agreed, I too thought that exchange of dialouge was pretty well executed.

As for me, my personal choice would be bringing Wrex and Liara on Noveria:

Shepard: "Let's not start a fight."
Wrex: "Why not?"

Wrex: "If they won't listen to reason then they are fools you should eat them*!"

Also:
Liara: "What was that?"
Wrex: "Probably debris don't have a panic attack.... I'll protect you."

Seriously, throughout the whole game Wrex was a joy to listen to, hence why I always took him with me in an elevator secretly hoping he'd exchange dialouge with the others.

As shown here:
http://www.youtube.com/watch?v=vOg-nLWe71w
Seriously, that Krogan is king in my eyes.

 

[darth gditch]

ME2, when attempting to recruit someone to your party, but he has a problem he needs your help with first.
Shepard: Just once, I'd like for someone to say "Yes, certainly, I'll help you save the galaxy! Just let me go grab my stuff!"

Funny enough, that's exactly along the lines of what Zaeed says.

 

[Bellvedere]

Mordin: "So don't *cough* ingest..."

I died. Like ded from the dying.



...[/youtube]

He gives you advice for Thane as well, something along the lines of "oral contact can has halucinations in humans."

And if you aren't romancing anyone he'll accuse you of always visiting and says that he's not interested in dating you.

Mordin is the greatest.

 

[Apocalypse Tank]

You sonuvabitch!
(After punching the interviewer in the face during the interview)

 

[Uilleand]

...also...
Joker is full of awesome...

"This is all Joker's fault. What a tool he was. I have to spend all day computing pi because he plugged in the Overlord"

"Leeaather..."

and...

"How d'ya like THAT, ya sonsofbitches!"

 

[camokkid]

All these are from ME2.

"That means Albert Einstein is the most dangerous mother****** in this damn galaxy! Now Private, what is Nikolai Tesla's Third Law?" Random group of soldiers in the Citadel.

Wow, you got that [i/]SO[/i] wrong.

It goes:

Sergeant:"That means: Sir Isaac Newton is the deadliest son of a ***** in space! Now, Serviceman Burnside, what is Newton's first law?"

Burnside:"Sir, an object in motion stays in motion, sir!"

Sergeant:"No credit for partial answers, maggot!"

Burnside:"Sir, unless acted on by an outside force sir!"

What game were you playing?

Albert Einstein, Nikola Tesla, and Isaac Newton are three completely different people!

 

[Undead Dragon King]

There's a little Easter Egg when you take Tali and Garrus to the Citadel in ME2. At some point when you're walking around, this comes up:

Garrus: Do you ever miss those talks we had on the elevators?

Tali: No.

Garrus: Come on, Remember when we all asked you about life on the flotilla? It was an opportunity to share!

Tali: This conversation is over.

Garrus: Tell me again about your immune system!

Tali: I have a shotgun.

Garrus: Mmmmmaybe we'll talk later.

I was laughing for a solid minute after that. Another one of my favorites is right after finishing the game:

Illusive Man: Shepard, once again you're proving to be more trouble than you're worth.

Shepard: Sorry, I can't hear you too well. I'm getting a lot of bullshit on this line.

Loved it!

 

[Undead Dragon King]

Also:

"Space Hamster: This furry rodent looks up at you with what seems like a knowing smile."

Tali: Go for the optics, Tjutika! Go for the optics!

My love of BioWare jumped when I saw those.

Go for the eyes, Boo! Go for the eyes, YEEEAAARRGGHH! *Squeak!*
Minsc will lead with blade and boot! Boo will take care of the details!

 

[Aeshi]

My favorite quote is probab-ASSUMING CONTROL!

 

[cormacdffy]

"I am the very model of a sciantist Salarian,
I study species Turian, Asari and Batarian"
-Mordin

I laughed my ass off when I first heard him sing lol

 

[AnAngryMoose]

Listener to the Salarian's bachelor party in that club on Illios (IIRC). That's just gold.

 

[Drops a Sweet Katana]

"You assume I give a damn. That's cute." Commander Shepard to the Crime boss (or something like that) on the mission where you have to defuse a nuclear warhead on an uncharted world.