I remember my first use of the Holy Hand Grenade in Worms. I was in kinda a bad situation where the enemy had a massive rock blocking them, but being CPUs, they had of course mastered using the wind to blow all their rockets right at me. I had used all my grenades at bad throws and just had the holy hand grenade left. So, I tried throwing that, and it bounced PERFECTLY into place, avoiding all the sinkholes nearby.
AAAAAA-LE-LU-YA. BOOM (kill x3)
In Wallace and Gromit, you temporarily get to use their classic Porridge Gun to shoot down bees.