http://news.yahoo.com/online-gamers-crack-aids-enzyme-puzzle-175427367.html
They might as well have called it "AIDS: The Virus-Cracking MMO".
They might as well have called it "AIDS: The Virus-Cracking MMO".
And gamers tasked to play --- literally unfolding an extremely complex HIV-related enzyme so that new treatments for it can be researched --- achieved in three weeks what mainstream science's automated processes have been unable to do for decades.Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV.
Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them.
But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that "unfolds" the molecule and rotates it in order to reveal potential targets for drugs.
This is where Foldit comes in.
Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids -- the building blocks of proteins -- using a set of online tools.