This is false, and a quick look on youtube can prove it.
Sam was able to crawl towards Nadie's gun that was had fallen. This wasn't BECAUSE they beat her. This was DESPITE that SHE beat THEM.
NEITHER SAM NOR NATE COULD LAND ONE SOLID HIT ON HER. EVER. The only time anyone got close is when Nate grappled with her and pushed her into a wall.
The floor collapsed, they were scattered, Nate crawls towards the gun, Nadine kicks Nate before he can reach it, and Sam crawls in from off-screen. That's the sequence of events here.
If I pull a gun (or two) on Mike Tyson, can I say that I beat him in a fight? That's essentially the argument you're using here.
If she beat them Sam wouldn't have been able to get the gun, he was still in the action. And this wasn't a fair boxing match, this was an already unfair advantage for Drake and Sam. The argument is that Nadine shouldn't be able to beat both of them at the same time, and she doesn't. Nate is able to get the drop on her when he drops on her from above as she's busy with Sam, and then Sam is able to get the gun and gain the advantage. That's Nadine losing the fight because she couldn't handle both of them at the same time.
And the reason she was able to kick their asses so thoroughly is easily excusable by the fact that she was most likely raised as a soldier due to her father being one, and Nate and Sam already pushing or exceeding forty, as well as Nate not having been in action for at least three years, and Sam being a heavy smoker.
But you know what, fine, yes, Nadine is presented very much as 'look how awesome and badass she is', but you know who else was presented like that? Talbot from
Uncharted 3, except WAY worse. Nadine is pretty much a less terrible, more visually interesting version of Talbot. Talbot is ten times the Mary Sue that Nadine is, yet he never gets brought up in the 'never should've been able to beat Drake' discussion. Certainly not by the crowd who cries Mary Sue. Or hey, remember Kai Leng? So politically motivated, him beating Shepard because the plot demanded it, right?
This all comes down to 'a woman beats Drake in a fight: IMPOSSIBLE'. Remember in
Uncharted 2 where Drake beats and shoots the shit out of a dude on a train, but then the guy comes to life and starts throttling Drake who is incapable of escaping his grasp, because the plot demanded it? Yeah, Drake has lost because the plot demanded it more than enough before Nadine, but it suddenly became an issue when Nadine, a woman, did it.