I'd respect it more if the same basic premise/joke hadn't been retreaded so many times. Mario as an addict because he uses mushrooms in the game to "power up". Various mushrooms being a recreational "drug" that can bring on hallucinations IRL. We've had fan comics, skits, live action movies, and cartoons all using the same basic joke.
I mean it's well made and all, and in a differant style, but to really get points from me I think something needs a unique spin on making fun of the Mario characters, or at least one that isn't so obvious and retreaded nowadays. Even if Mario isn't literally addicted to Mushrooms it's like hearing a joke you've already heard for like the 200th time.
That's just my opinion, it's not that the skit is bad (it's not in any objective sense) just nothing special as the material itself ruins it by being overused.