Drakmorg said:
"Sorry for twisting your DNA like a kitten with a ball of yarn"
might not be all that obscure now that I think about it, but it's all I can think of right now.
Fallout 3, after being irradiated for that writer in Megaton.
" However, after carefully reviewing the terms of your proposal, I am saddened to inform you that I must reject it. Although the benefits of regional peace are many, I simply am sickened at the thought of entering ANY kind of pact with sich a despicable worm as yourself. I am amazed... no, aghast by your thinking for one moment that I would disgrace myself by joining with YOU in any endeavor, save war. You are unworthy of my further attention, Hajod."
It's a big one, cause this is a REALLY obscure game.